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Aberrant Pim-3 expression is involved in gastric adenoma–adenocarcinoma sequence and cancer progression

Zheng, Hua-Chuan ; Tsuneyama, Koichi ; Takahashi, Hiroyuki ; Miwa, Shigeharu ; Sugiyama, Toshiro ; Popivanova, Boryana Konstantinova ; Fujii, Chifumi ; Nomoto, Kazuhiro ; Mukaida, Naofumi ; Takano, Yasuo

Journal of cancer research and clinical oncology, 2008-04, Vol.134 (4), p.481-488 [同儕審閱期刊]

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Aberrant Pim-3 expression is involved in gastric adenoma–adenocarcinoma sequence and cancer progression
著者: Zheng, Hua-Chuan ; Tsuneyama, Koichi ; Takahashi, Hiroyuki ; Miwa, Shigeharu ; Sugiyama, Toshiro ; Popivanova, Boryana Konstantinova ; Fujii, Chifumi ; Nomoto, Kazuhiro ; Mukaida, Naofumi ; Takano, Yasuo
主題: Adenocarcinoma - blood supply ; Adenocarcinoma - chemistry ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenoma - blood supply ; Adenoma - chemistry ; Adenoma - mortality ; Adenoma - pathology ; Adult ; Aged ; Antigens, CD34 - analysis ; Antineoplastic agents ; Biological and medical sciences ; Cancer ; Cancer Research ; Disease Progression ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal diseases ; Gene expression ; Hematology ; Humans ; Immunohistochemistry ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Paper ; Pathology ; Pharmacology. Drug treatments ; Protein-Serine-Threonine Kinases - analysis ; Proto-Oncogene Proteins - analysis ; Stomach Neoplasms - blood supply ; Stomach Neoplasms - chemistry ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tissue Array Analysis ; Tumors ; Vascular Endothelial Growth Factor A - analysis
所屬期刊: Journal of cancer research and clinical oncology, 2008-04, Vol.134 (4), p.481-488
描述: Purpose Pim-3, a member of the proto-oncogene Pim family with serine/threonine kinase activity was aberrantly expressed in cancerous lesions of endoderm-derived organs such as liver, pancreas, and colon. The aim of this study was to clarify the role of Pim-3 expression in the tumorigenesis and the development of gastric carcinomas. Methods Pim-3 expression was immunohistochemically examined on the tissue microarrays containing primary ( n = 285) and metastastic ( n = 37) sites of gastric carcinomas, in comparison with adenoma ( n = 48) and non-cancerous mucosa ( n = 84). It was also compared with the clinicopathological parameters of gastric carcinomas. Results Pim-3 expression was enhanced in adenoma (64.6%) and metastasis sites of gastric carcinoma (73.0%), to a lesser degree in primary sites of gastric carcinoma (39.3%) when compared to non-cancerous mucosa (13.1%, p < 0.0001). Pim-3 expression levels were higher in intestinal-type than diffuse-type gastric carcinoma ( p = 0.018). Pim-3 expression was closely correlated with sex ( p = 0.047), lymphatic ( p = 0.019) and venous invasion ( p = 0.014). Pim-3 expression was correlated significantly with vascular endothelial growth factor (VEGF, p = 0.009) and extracellular matrix metalloproteinase inducer (EMMPRIN, p = 0.032), both of which are presumed to be involved in neovascularization, a crucial step for metastasis. On the contrary, phosphatase and tensin homology deleted from human chromosome 10 (Pten) negative gastric carcinomas exhibited higher Pim-3 expression than Pten positive ones ( p = 0.042). There was no relationship between Pim-3 expression and MVD in gastric carcinomas ( p = 0.715). Furthermore, patients with Pim-3 positive gastric cancer, showed a lower cumulative survival rate than those with Pim-3 negative gastric cancer ( p = 0.014) and Pim-3 positive was also identified as an independent prognostic factor for gastric carcinoma patients ( p = 0.006). Conclusions Aberrant Pim-3 expression was involved in gastric adenoma–adenocarcinoma sequence and subsequent invasion and metastasis process in gastric cancer. Moreover, Pim-3 may be employed to predict the prognosis of gastric cancer patients. Distinct Pim-3 expression underlies the molecular mechanisms for the differentiation of intestinal-type and diffuse-type carcinomas.
出版者: Berlin/Heidelberg: Springer-Verlag
語言: 英文
識別號: ISSN: 0171-5216
EISSN: 1432-1335
DOI: 10.1007/s00432-007-0310-1
PMID: 17876606
CODEN: JCROD7
資源來源: Springer journals

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Aberrant Pim-3 expression is involved in gastric adenoma–adenocarcinoma sequence and cancer progression

Zheng, Hua-Chuan ; Tsuneyama, Koichi ; Takahashi, Hiroyuki ; Miwa, Shigeharu ; Sugiyama, Toshiro ; Popivanova, Boryana Konstantinova ; Fujii, Chifumi ; Nomoto, Kazuhiro ; Mukaida, Naofumi ; Takano, Yasuo

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