語言:

Principles and challenges of genome-wide DNA methylation analysis

Laird, Peter W

Nature reviews. Genetics, 2010-03, Vol.11 (3), p.191-203 [同儕審閱期刊]

可取得全文

引用被引用

題名:
Principles and challenges of genome-wide DNA methylation analysis
著者: Laird, Peter W
主題: Biological and medical sciences ; DNA damage ; Epigenetic inheritance ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Physiological aspects
所屬期刊: Nature reviews. Genetics, 2010-03, Vol.11 (3), p.191-203
描述: Methylation of cytosine bases in DNA provides a layer of epigenetic control in many eukaryotes that has important implications for normal biology and disease. Therefore, profiling DNA methylation across the genome is vital to understanding the influence of epigenetics. There has been a revolution in DNA methylation analysis technology over the past decade: analyses that previously were restricted to specific loci can now be performed on a genome-scale and entire methylomes can be characterized at single-base-pair resolution. However, there is such a diversity of DNA methylation profiling techniques that it can be challenging to select one. This Review discusses the different approaches and their relative merits and introduces considerations for data analysis.
出版者: London: Nature Publishing Group
語言: 英文
識別號: ISSN: 1471-0056
EISSN: 1471-0064
DOI: 10.1038/nrg2732
資源來源: Academic Search Premier

連結

返回到檢索清單