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Principles and challenges of genome-wide DNA methylation analysis

Laird, Peter W

Nature reviews. Genetics, 2010-03, Vol.11 (3), p.191-203 [Peer Reviewed Journal]

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Title:
Principles and challenges of genome-wide DNA methylation analysis
Author: Laird, Peter W
Subjects: Biological and medical sciences ; DNA damage ; Epigenetic inheritance ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Physiological aspects
Is Part Of: Nature reviews. Genetics, 2010-03, Vol.11 (3), p.191-203
Description: Methylation of cytosine bases in DNA provides a layer of epigenetic control in many eukaryotes that has important implications for normal biology and disease. Therefore, profiling DNA methylation across the genome is vital to understanding the influence of epigenetics. There has been a revolution in DNA methylation analysis technology over the past decade: analyses that previously were restricted to specific loci can now be performed on a genome-scale and entire methylomes can be characterized at single-base-pair resolution. However, there is such a diversity of DNA methylation profiling techniques that it can be challenging to select one. This Review discusses the different approaches and their relative merits and introduces considerations for data analysis.
Publisher: London: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-0056
EISSN: 1471-0064
DOI: 10.1038/nrg2732
Source: EBSCOhost Academic Search Premier

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