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耐力訓練與飲食限制對大鼠血中IGF-1及IGFBP-3之影響
陳建瑋; Chen, Chien-wei 劉立宇; none; 體育學系碩士班 2011
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題名:
耐力訓練與飲食限制對大鼠血中IGF-1及IGFBP-3之影響
著者:
陳建瑋
;
Chen, Chien-wei
劉立宇
;
none
;
體育學系碩士班
主題:
IGF-1
;
酵素活性
;
飲食限制
;
耐力運動
;
IGFBP-3
;
IGF-1
;
enzymes activity
;
calorie restriction
;
endurance training
;
IGFBP-3
描述:
目的:本研究旨在探討8週耐力訓練與飲食限制對大鼠血中IGF-1及IGFBP-3之影響。方法:雄性Wistar大鼠48隻(週齡:7週),隨機分成(每組n=12)低強度訓練組(LIT組)、高強度訓練組(HIT組)、控制組(CON組)及飲食控制組(DCON組)。運動組進行為期8週的跑步機運動訓練,每週訓練5天,每天訓練時間為60分鐘;為使DCON組體重與運動組之減重情形相同,每日給予DCON組的飼料為運動組平均飲食量之80至90%,其他組別則採自由取食方式;每週記錄兩次體重,八週實驗結束後進行動物犧牲,所取得的血液及肌肉組織進行血中類胰島素生長因子 (IGF-1) 、類胰島素結合蛋白第三型 (IGFBP-3) 、骨骼肌有氧代謝酵素檸檬酸合成酶 (CS) 與3-羥醯基輔酶A脫氫酶 (3-HAD) 及骨骼肌無氧代謝酵素磷酸果糖激酶 (PFK) 與乳酸脫氫酶 (LDH) 之測量。結果:兩組訓練組與DCON組的體重增加輻度一致,皆顯著低於CON組(p<.05),比目魚肌重量此三組也顯著低於CON組 (p<.05) ,此外伸趾長肌四組間無顯著差異;在骨骼肌能量代謝酵素方面,以第一型肌纖維為主的比目魚肌,其CS與3-HAD活性都呈現兩組運動組顯著高於CON組與DCON組的現象 ( p<.05) 、PFK則是DCON組顯著低於其他三組 (p<.05) 、LDH活性則為LIT組顯著高於CON組與HIT組 (p<.05) 。另外以第二型肌纖維為主的伸趾長肌方面,CS活性為LIT組顯著低於其他三組(p<.05)、PFK則是HIT組顯著高於CON組與DCON組 (p<.05) 、LDH活性為DCON組大於LIT組 (p<.05) ;另外,DCON組的IGF-1顯著低於其他三組 (p<.05) 、IGFBP-3與IGF-1/IGFBP-3四組之間則無顯著差異 (p>.05) 。結論:耐力訓練組有助於提升粒線體有氧代謝酵素速之活性,此外飲食限制組達到降低血中IGF-1濃度的效果,但8週耐力訓練無法降低血中IGF-1濃度,且八週的耐力訓練與飲食限制皆無法有效造成IGFBP-3濃度之變動。
Purpose: The aim of this study was to investigate the effects of endurance running and calorie restriction on blood IGF-1, IGFBP-3 in male rat. Methods: Forty-eight male Wistar rats (7 weeks old) were randomly assigned into four groups, which were low intensity training group (LIT, n=12), high intensity training group (HIT, n=12), control group (CON, n=12), and diet control group (DCON, n=12). Animals in the HIT and LIT groups underwent endurance training at speed of 12m/min~22m/min and 15m/min~28m/min, respectively, on the treadmill 5 days per week for 8weeks. To match the body weight gain of the exercise group, the DCON rats received 80%~90% mean quantity of chow consumed by exercise groups. Other groups were fed with rodent diet and distilled water ad libitum. The body weight of each animal was measured twice a week. The end of 8-weeks training program, all animals (15 weeks old) were sacrificed. Blood and muscle samples were collected and stored for further serum marker and muscle enzymes assay, including insulin-like growth factor (IGF-1), insulin-like growth factor binding proteins-3 (IGFBP-3), citrate synthase (CS), 3-hydroxyacyl-CoA-dehydrogenase (3-HAD), phosphofructokinase (PFK) and lactate dehydrogenase (LDH) analysis. Result: Body weight gain was significantly higher in the CON group as compared with other three groups (p<.05). And soleus (SOL) weight was significantly higher in the CON group as compared with other three groups (p<.05). Extensor digitorum longus (EDL) showed no significant level among groups (p>.05). The CS and 3-HAD activity in SOL (predominantly type I fibers), it’s LIT and HIT groups showed a significantly higher than CON and DCON groups (p<.05). The PFK activity assay, DCON group was showed a nonsignificantly between four groups (p<.05). And the LDH activity, it’s LIT groups showed a significantly higher than CON and HIT groups (p<.05). In the DCON group, serum IGF-I concentration were significantly lower than other three groups (p<.05). Furthermore, the IGFBP-3 and IGF-1/IGFBP-3 showed a nonsignificantly between four groups. Conclusion: Regardless of the intensity of exercise, the study showed that the eight weeks endurance training can enhance the aerobic-oxidative metabolic enzymes activity of mitochondrial, but not significantly reduced IGF-1 concentrations in blood. In addition, calorie restriction can significantly reduced IGF-1 concentrations in blood. Furthermore, this study showed that the eight weeks endurance running and calorie restriction can not changed of IGFBP-3 level.
碩士
建立日期:
2011
格式:
121 bytes
text/html
語言:
中文
識別號:
http://nutnr.lib.nutn.edu.tw/handle/987654321/1884
資源來源:
NUTN IR
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