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Assembly Rules of the Microbiome.

Roie. Levy University of Washington. Molecular and Cellular Biology. 2015

Dissertation Abstracts International 76-08B(E).

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題名:
Assembly Rules of the Microbiome.
著者: Roie. Levy
University of Washington. Molecular and Cellular Biology.
主題: Genetics
所屬期刊: Dissertation Abstracts International 76-08B(E).
描述: The microbiome - the communal ecosystem of bacteria, archaea, and microscopic eukarya as well as the environments sustaining them - surpasses its macroscopic counterpart in taxonomic diversity, metabolic capabilities, and biogeographical distribution. Microbes inhabit every habitat hospitable to life, even those too extreme for higher order organisms. In milder environments, microbes provide the foundation for all life, either by maintaining essential biogeochemical cycles or by directly supporting host macroorganism health. These microbes interact to form complex communities, some of which contain up to thousands of distinct species. Modern metagenomic techniques have revealed extensive structure in these communities in the form of non-random species co-occurrence patterns. It has been proposed that patterns such as these arise through cogent assembly rules - deterministic ecological processes that govern the characteristic structure of a community. Yet, because the physiology and behavior of only a tiny fraction of microorganisms has been characterized, it becomes challenging to distinguish between alternative sets of community assembly rules. In this dissertation, I describe work l performed during my doctoral studies to develop analytical frameworks that integrate community metagenome information with single species whole genome information to identify community assembly rules that structure the human and global microbiomes. In chapter 1 I discuss the context for this work: the microbial communities studied, the methods used to characterize them, and the specific challenges I aim to address. In chapter 2 I describe how I used metabolic models of species interaction to determine that habitat filtering, and not species assortment, determines the structure of the human microbiome. These models additionally showed that host intestinal health state does not define the axes along which the community is filtered, hinting at more subtle biochemical processes yet to b
出版者: Thesis (Ph.D.)--University of Washington, 2015.
建立日期: 2015
格式: 180 p..
語言: 英文
識別號: ISBN9781321678574
資源來源: NUTN ALEPH

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Assembly Rules of the Microbiome.

Roie. Levy University of Washington. Molecular and Cellular Biology. 2015

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