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Survival of the weakest in non-transitive asymmetric interactions among strains of E. coli

Liao, Michael J ; Miano, Arianna ; Nguyen, Chloe B ; Chao, Lin ; Hasty, Jeff

Nature communications, 2020-11, Vol.11 (1), p.6055-6055, Article 6055 [同儕審閱期刊]

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題名:
Survival of the weakest in non-transitive asymmetric interactions among strains of E. coli
著者: Liao, Michael J ; Miano, Arianna ; Nguyen, Chloe B ; Chao, Lin ; Hasty, Jeff
主題: Asymmetry ; Biodiversity ; Cell membranes ; Computer applications ; Computer Simulation ; Deoxyribonucleic acid ; DNA ; Dominant species ; E coli ; Ecology ; Escherichia coli - cytology ; Escherichia coli - genetics ; Escherichia coli - immunology ; Immunity - genetics ; Maintenance ; Microbial activity ; Microbial Viability ; Microorganisms ; Models, Biological ; Strains (organisms) ; Toxins ; Warfare
所屬期刊: Nature communications, 2020-11, Vol.11 (1), p.6055-6055, Article 6055
描述: Hierarchical organization in ecology, whereby interactions are nested in a manner that leads to a dominant species, naturally result in the exclusion of all but the dominant competitor. Alternatively, non-hierarchical competitive dynamics, such as cyclical interactions, can sustain biodiversity. Here, we designed a simple microbial community with three strains of E. coli that cyclically interact through (i) the inhibition of protein production, (ii) the digestion of genomic DNA, and (iii) the disruption of the cell membrane. We find that intrinsic differences in these three major mechanisms of bacterial warfare lead to an unbalanced community that is dominated by the weakest strain. We also use a computational model to describe how the relative toxin strengths, initial fractional occupancies, and spatial patterns affect the maintenance of biodiversity. The engineering of active warfare between microbial species establishes a framework for exploration of the underlying principles that drive complex ecological interactions.
出版者: England: Nature Publishing Group
語言: 英文
識別號: ISSN: 2041-1723
EISSN: 2041-1723
DOI: 10.1038/s41467-020-19963-8
PMID: 33247128
資源來源: Publicly Available Content Database
DOAJ Directory of Open Access Journals

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Survival of the weakest in non-transitive asymmetric interactions among strains of E. coli

Liao, Michael J ; Miano, Arianna ; Nguyen, Chloe B ; Chao, Lin ; Hasty, Jeff

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