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Nanohole-boosted electron transport between nanomaterials and bacteria as a concept for nano-bio interactions
Shi, Tonglei ; Hou, Xuan ; Guo, Shuqing ; Zhang, Lei ; Wei, Changhong ; Peng, Ting ; Hu, Xiangang
Nature communications, 2021-01, Vol.12 (1), p.493-15, Article 493
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題名:
Nanohole-boosted electron transport between nanomaterials and bacteria as a concept for nano-bio interactions
著者:
Shi, Tonglei
;
Hou, Xuan
;
Guo, Shuqing
;
Zhang, Lei
;
Wei, Changhong
;
Peng, Ting
;
Hu, Xiangang
主題:
Animal models
;
Animals
;
Anti-Bacterial Agents - administration & dosage
;
Antibacterial agents
;
Antibiotics
;
Bacteria
;
Bacterial diseases
;
Bacterial infections
;
Biocompatibility
;
Biofilms
;
Biofilms - drug effects
;
Caco-2 Cells
;
Cell membranes
;
Critical components
;
Damage
;
Deoxyribonucleic acid
;
DNA
;
Donors (electronic)
;
Drug resistance
;
Electron transport
;
Electron Transport - drug effects
;
Gene expression
;
Health risks
;
Humans
;
Infections
;
Intestine
;
Mice
;
Mice, Inbred ICR
;
Microbial Sensitivity Tests
;
Nanomaterials
;
Nanostructures - administration & dosage
;
Nanotechnology
;
Polysaccharides
;
Rats
;
Rats, Sprague-Dawley
;
Reactive oxygen species
;
Saccharides
;
Staphylococcal Infections - drug therapy
;
Staphylococcal Infections - microbiology
;
Staphylococcus aureus - drug effects
;
Staphylococcus aureus - physiology
;
Transition metals
所屬期刊:
Nature communications, 2021-01, Vol.12 (1), p.493-15, Article 493
描述:
Biofilms contribute to bacterial infection and drug resistance and are a serious threat to global human health. Antibacterial nanomaterials have attracted considerable attention, but the inhibition of biofilms remains a major challenge. Herein, we propose a nanohole-boosted electron transport (NBET) antibiofilm concept. Unlike known antibacterial mechanisms (e.g., reactive oxygen species production and cell membrane damage), nanoholes with atomic vacancies and biofilms serve as electronic donors and receptors, respectively, and thus boost the high electron transport capacity between nanomaterials and biofilms. Electron transport effectively destroys the critical components (proteins, intercellularly adhered polysaccharides and extracellular DNA) of biofilms, and the nanoholes also significantly downregulate the expression of genes related to biofilm formation. The anti-infection capacity is thoroughly verified both in vitro (human cells) and in vivo (rat ocular and mouse intestinal infection models), and the nanohole-enabled nanomaterials are found to be highly biocompatible. Importantly, compared with typical antibiotics, nanomaterials are nonresistant and thereby exhibit high potential for use in various applications. As a proof-of-principle demonstration, these findings hold promise for the use of NBET in treatments for pathogenic bacterial infection and antibiotic drug resistance.
出版者:
England: Nature Publishing Group
語言:
英文
識別號:
ISSN: 2041-1723
EISSN: 2041-1723
DOI: 10.1038/s41467-020-20547-9
PMID: 33479209
資源來源:
Publicly Available Content Database
DOAJ Directory of Open Access Journals
連結
View this record in MEDLINE/PubMed
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