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Allostery: An Overview of Its History, Concepts, Methods, and Applications

Liu, Jin ; Nussinov, Ruth

PLoS computational biology, 2016-06, Vol.12 (6), p.e1004966-e1004966 [同儕審閱期刊]

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題名:
Allostery: An Overview of Its History, Concepts, Methods, and Applications
著者: Liu, Jin ; Nussinov, Ruth
主題: Allosteric Regulation ; Biochemistry - history ; Biology and Life Sciences ; Biomedical research ; Biomedical Research - history ; Computational biology ; Crystal structure ; Crystallography ; Disease ; Evolution ; Funding ; History, 20th Century ; History, 21st Century ; Humans ; Kinases ; Medicine and Health Sciences ; Models, Biological ; NMR ; Nuclear magnetic resonance ; Physical Sciences ; Proteins ; R&D ; Research & development ; Research and analysis methods ; Studies
所屬期刊: PLoS computational biology, 2016-06, Vol.12 (6), p.e1004966-e1004966
描述: The concept of allostery has evolved in the past century. In this Editorial, we briefly overview the history of allostery, from the pre-allostery nomenclature era starting with the Bohr effect (1904) to the birth of allostery by Monod and Jacob (1961). We describe the evolution of the allostery concept, from a conformational change in a two-state model (1965, 1966) to dynamic allostery in the ensemble model (1999); from multi-subunit (1965) proteins to all proteins (2004). We highlight the current available methods to study allostery and their applications in studies of conformational mechanisms, disease, and allosteric drug discovery. We outline the challenges and future directions that we foresee. Altogether, this Editorial narrates the history of this fundamental concept in the life sciences, its significance, methodologies to detect and predict it, and its application in a broad range of living systems.
出版者: United States: Public Library of Science
語言: 英文
識別號: ISSN: 1553-7358
ISSN: 1553-734X
EISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1004966
PMID: 27253437
資源來源: Publicly Available Content Database
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DOAJ Directory of Open Access Journals

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Allostery: An Overview of Its History, Concepts, Methods, and Applications

Liu, Jin ; Nussinov, Ruth

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