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The pathogenesis of human cytomegalovirus

Griffiths, Paul ; Baraniak, Ilona ; Reeves, Matt

The Journal of pathology, 2015-01, Vol.235 (2), p.288-297 [同儕審閱期刊]

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題名:
The pathogenesis of human cytomegalovirus
著者: Griffiths, Paul ; Baraniak, Ilona ; Reeves, Matt
主題: Animals ; Antiviral Agents - therapeutic use ; congenital ; Cytomegalovirus - drug effects ; Cytomegalovirus - genetics ; Cytomegalovirus - immunology ; Cytomegalovirus - pathogenicity ; Cytomegalovirus Infections - drug therapy ; Cytomegalovirus Infections - epidemiology ; Cytomegalovirus Infections - immunology ; Cytomegalovirus Infections - pathology ; Cytomegalovirus Infections - transmission ; Cytomegalovirus Infections - virology ; Cytomegalovirus Vaccines - therapeutic use ; Genotype ; Host-Pathogen Interactions ; Human cytomegalovirus ; Humans ; pre-emptive therapy ; Prognosis ; Risk Factors ; threshold ; transplantation ; viraemia ; Virulence
所屬期刊: The Journal of pathology, 2015-01, Vol.235 (2), p.288-297
描述: Human cytomegalovirus (HCMV) is a recognized cause of disease in the fetus, the allograft recipient and AIDS patients. More recently, it has been recognized as a pathogen for those admitted to intensive care units, for the elderly and for the general population. The epidemiology and molecular and cellular pathology of this virus are summarized to provide an overarching model of pathogenesis, able to account for these varying clinical presentations. In brief, HCMV has the potential to spread in the bloodstream to all organs, but only produces overt disease if the viral load increases to high levels. This is normally prevented by a robust immune response, so that the infected individual usually remains asymptomatic. However, this benefit comes at the cost of committing more and more immunological resources to controlling HCMV with time, so that the overall function of the immune system is impaired. Fortunately, recent progress in developing novel antiviral drugs and vaccines suggests the possibility that the diverse effects of HCMV may soon become controllable at the individual and population level, respectively. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
出版者: Chichester, UK: John Wiley & Sons, Ltd
語言: 英文
識別號: ISSN: 0022-3417
EISSN: 1096-9896
DOI: 10.1002/path.4437
PMID: 25205255
資源來源: Wiley Blackwell Journals
Wiley Online Library

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The pathogenesis of human cytomegalovirus

Griffiths, Paul ; Baraniak, Ilona ; Reeves, Matt

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