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Early symptoms of autism spectrum disorder (ASD) in 1–8 year old children with sex chromosome trisomies (XXX, XXY, XYY), and the predictive value of joint attention

Bouw, Nienke ; Swaab, Hanna ; Tartaglia, Nicole ; Wilson, Rebecca L. ; Van der velde, Kim ; van Rijn, Sophie

European child & adolescent psychiatry, 2023-11, Vol.32 (11), p.2323-2334 [同儕審閱期刊]

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題名:
Early symptoms of autism spectrum disorder (ASD) in 1–8 year old children with sex chromosome trisomies (XXX, XXY, XYY), and the predictive value of joint attention
著者: Bouw, Nienke ; Swaab, Hanna ; Tartaglia, Nicole ; Wilson, Rebecca L. ; Van der velde, Kim ; van Rijn, Sophie
主題: Attention ; Autism ; Autism Spectrum Disorder - complications ; Autism Spectrum Disorder - diagnosis ; Autism Spectrum Disorder - genetics ; Autistic children ; Child ; Child and Adolescent Psychiatry ; Child development ; Child, Preschool ; Childhood ; Children ; Chromosomes ; Communication ; Genetics ; Humans ; Infant ; Joint attention ; Karyotypes ; Longitudinal Studies ; Medicine ; Medicine & Public Health ; Neurobehavioral functioning ; Neurodevelopment ; Original Contribution ; Predictions ; Psychiatry ; Recruitment ; Risk ; Sex Chromosomes ; Social development ; Social functioning ; Social interaction ; Subtypes ; Symptoms ; Toddlers ; Trisomy ; Trisomy - diagnosis ; Trisomy - genetics
所屬期刊: European child & adolescent psychiatry, 2023-11, Vol.32 (11), p.2323-2334
描述: The objective of the present study is to investigate the impact of Sex Chromosome Trisomy (SCT; XXX, XXY, XYY) on the early appearance of Autism Spectrum Disorder (ASD) symptoms, and the predictive value of Joint Attention for symptoms of ASD. SCTs are specific genetic conditions that may serve as naturalistic ‘at risk’ models of neurodevelopment, as they are associated with increased risk for neurobehavioral vulnerabilities. A group of 82 children with SCT (aged 1–8 years) was included at baseline of this longitudinal study. Joint Attention was measured at baseline with structured behavior observations according to the Early Social Communication Scales. ASD symptoms were assessed with the Modified Checklist for Autism in Toddlers questionnaire and Autism Diagnostic Interview-Revised in a 1-year follow-up. Recruitment and assessment took place in the Netherlands and in the United States. The results demonstrate that ASD symptoms were substantially higher in children with SCT compared to the general population, with 22% of our cohort at clinical risk for ASD, especially in the domain of social interaction and communication. Second, a predictive value of Joint Attention was found for ASD symptoms at 1-year follow-up. In this cohort, no differences were found between karyotype-subtypes. In conclusion, from a very early age, SCT can be associated with an increased risk for vulnerabilities in adaptive social functioning. These findings show a neurodevelopmental impact of the extra X or Y chromosome on social adaptive development associated with risk for ASD already from early childhood onward. These findings advocate for close monitoring and early (preventive) support, aimed to optimize social development of young children with SCT.
出版者: Berlin/Heidelberg: Springer Berlin Heidelberg
語言: 英文
識別號: ISSN: 1018-8827
EISSN: 1435-165X
DOI: 10.1007/s00787-022-02070-y
PMID: 36107256
資源來源: SpringerLink (Online service)

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