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Schizencephaly revisited

Griffiths, Paul D.

Neuroradiology, 2018-09, Vol.60 (9), p.945-960 [同儕審閱期刊]

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題名:
Schizencephaly revisited
著者: Griffiths, Paul D.
主題: Abnormalities ; Adolescent ; Brain ; Child ; Child, Preschool ; Children ; Classification ; Classification systems ; Cortex ; Female ; Fetal Diseases - diagnostic imaging ; Fetuses ; Humans ; Imaging ; Infant ; Infant, Newborn ; Literature reviews ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine & Public Health ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Paediatric Neuroradiology ; Pediatrics ; Pregnancy ; Radiology ; Schizencephaly - diagnostic imaging ; Septum
所屬期刊: Neuroradiology, 2018-09, Vol.60 (9), p.945-960
描述: Purpose In this paper, I will report the range of appearances of schizencephaly in children and fetuses by reviewing a 10-year experience from a single centre and detail classification systems for the different forms of schizencephaly. This will lead to re-assessment of possible aetiological and mechanistic causes of schizencephaly. Methods All cases of pediatric and fetal schizencephaly were located on the local database between 2007 and 2016 inclusive. The studies were reviewed for the presence, location and type of schizencephaly, as well as the state of the (cavum) septum pellucidum, the location of the fornices and the presence of other brain abnormalities. Results The review included 21 children and 11 fetuses with schizencephaly. Schizencephaly (type 1) was found in 9% of children but no fetuses, schizencephaly (type 2) was present in 67% of the pediatric cases and in 45% of fetuses, whilst schizencephaly (type 3) was present in approximately 24% of children and 55% of fetuses. Other brain abnormalities were found in 67% of children and 55% of fetuses. Conclusion I have proposed a new system for classifying schizencephaly that takes into account all definitions of the abnormality in the literature. Using that approach, I have described the appearances and associations of pediatric and fetal cases of schizencephaly from a single centre. Review of the current literature appears to favour an acquired destructive aetiology for most cases of schizencephaly, and I have proposed a mechanism to explain the cortical formation abnormalities found consistently in and around areas of schizencephaly.
出版者: Berlin/Heidelberg: Springer Berlin Heidelberg
語言: 英文
識別號: ISSN: 0028-3940
EISSN: 1432-1920
DOI: 10.1007/s00234-018-2056-7
PMID: 30027296
資源來源: Springer Nature Complete Springer Journals

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Schizencephaly revisited

Griffiths, Paul D.

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